Open Critical Care Grand Rounds Collective

HomeProfessionalsClinical ResourcesCritical CareClinical EducationOpen Critical Care Grand Rounds Collective ▶ How the World Changed in 12 weeks, 2019-nCoV, NCIP, SARS-CoV-2, COVID-19
How the World Changed in 12 weeks, 2019-nCoV, NCIP, SARS-CoV-2, COVID-19

Summary: The history of COVID-19, the disease course, and what treatments are being investigated

Speaker: Lindsey R. Baden, MD
Director of Clinical Research in the Division of Infectious Diseases at the Brigham and Women’s Hospital
Director of Infectious Diseases at the Dana-Farber Cancer Institute
Associate Professor at the Harvard Medical School

Video Editor: Kyle Swartz, DO


Key points

  • The coronavirus likely originated from a wet market in Wuhan, China and since has spread rapidly person to person. A true spectrum of illness is difficult to differentiate as only more severe cases are being tested. Even a low severity of illness is worrisome in a globally naive population.

  • COVID-19 case fatality rate increases with age. It is a biphasic illness with a viral and an inflammatory phase. The virus is highly contagious and difficult to contain as it has a large viral load in the upper respiratory tract, an infectious incubation phase, and a possible post illness viral shedding phase.

  • There are no antiviral therapies currently with supportive care the only treatment. Many studies are underway to investigate therapies including Lopinavir-Ritonavir, Hydroxychloroquine, IL-6 inhibitors, convalescent plasma and more.


The protocols and recommendations described in these videos do not constitute medical advice or treatment nor should they be considered replacement of the patient / physician relationship or a physicians professional judgement. ATS and the creators of the videos disclaims all liability for treatment, diagnosis, decisions and actions taken or not taken in reliance of information taken from this website.