Lung Transplantation

Annual ISHLT Registry Report

Khush KK, Cherikh WS, Chambers DC, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report-2018; Focus Theme: Multiorgan Transplantation. J Heart Lung Transplant. 2018; 37:1155-1168. This report provides an updated summary of transplant volumes, donor and recipient demographics and characteristics, as well as outcomes after transplant. This update’s focus theme is multiogran transplantation.

PMID: 30293612

Recipient Selection

Weill D, Benden C, Corris PA, et al. A consensus document for the selection of lung transplant candidates: 2014- An update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2015;34:1-15. Provides disease-specific summaries of indications and contraindications for transplantation, as well as recommendations for timing of referral.

PMID: 25085497

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Donor Selection and Management

Courtwright A, Cantu E. Evaluation and Management of the Potential Lung Donor. Clin Chest Med. 2017 Dec;38(4):751-759. Provides a review on the selection, assessment, and management of potential donor organs.

Post Transplant Management

Adegunsoye A,  Strek ME, Garrity E, et al. Comprehensive care of the lung transplant patient. Chest. 2017; 152:150-64. This review provides a concise overview of the management of patients awaiting transplant and as well as recipients.

PMID: 27729262

Scheffert JL, Raza K. Immunosuppression in lung transplantation. J Thorac Dis. 2014; 6:1039-53. Provides a nice overview of induction and maintenance therapies for lung transplant with an emphasis on pharmacotherapy.

PMID: 25132971

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Ahmad S, Shlobin OA, Nathan SD. Pulmonary complications of lung transplantation. Chest 2011;139:402-11. In addition to various forms of rejection, this review discusses infectious and airway complications.

PMID: 21285054

Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest 2017; 152:627-38. This article reviews the risk factors, clinical manifestations, and treatments of airway complications following lung transplantation.

PMID: 28274791

Meyer KC, Raghu G, Verleden GM, et al. An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. Eur Respir J. 2014; 44:1479-503. This guideline covers the definition, diagnosis, and treatment of BOS.

PMID: 25359357

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Verleden SE, Ruttens D, Vandermeulen E, et al. Restrictive chronic lung allograft dysfunction: where are we now? J Heart Lung Transplant. 2015; 34:625-30. A restrictive form of chronic lung allograft dysfunction is increasingly recognized as an important contributor to reduced survival following transplant. This review summarizes the mechanism, clinical presentation, diagnosis, and prognosis of this entity.

PMID: 25577564

Tikkanen JM, Singer LG, Kim SJ, et al. De novo DQ donor-specific antibodies are associated with chronic lung allograft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2016;194:596-606. A single-center cohort of 340 lung transplant recipients who underwent HLA-antibody testing quarterly pretransplant and at regular intervals over the first 24 months after transplant. The cumulative incidence of de novo DSA was 47% at a median of 86 days after lung transplantation with 76% of recipients with DQ-DSA. Developing de novo DSA was associated with a twofold increased risk of CLAD (hazard ratio, 2.04; 95% confidence interval, 1.13-3.69). This association appears to be driven by the development of DQ-dnDSA.

PMID: 26967790

Hathorn KE, Chan WW, Lo WK. Role of gastroesophageal reflux disease in lung transplantation. World J Transplant. 2017; 7:103-16. GERD is associated with worse outcomes following transplant. This paper reviews the pathophysiology, evaluation, and management of GERD in this population.

PMID: 28507913

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The following link provides on-going and up to date information on lung transplantation around the world including survival data: